Scaffold-Hopping Cascade Yields Potent Inhibitors of 5-Lipoxygenase

被引：32

作者：

Hofmann, Bettina ^{[1
]}

Franke, Lutz ^{[1
]}

Proschak, Ewgenij ^{[1
]}

Tanrikulu, Yusuf ^{[1
]}

Schneider, Petra ^{[2
]}

Steinhilber, Dieter ^{[3
]}

Schneider, Gisbert ^{[1
]}

机构：

[1] Univ Frankfurt, Inst Organ Chem & Chem Biol, ZAFES CMP, D-60323 Frankfurt, Germany

[2] Schneider Consulting GbR, D-61440 Oberursel, Germany

[3] Univ Frankfurt, Inst Pharmaceut Chem, ZAFES, D-60438 Frankfurt, Germany

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 10期

关键词：

bioisosters; cheminformatics; drug discovery; inflammation; virtual screening;

D O I：

10.1002/cmdc.200800153

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Chemical Equation Presented) A two-step iterative approach to virtual screening can identifypotent lead scaffolds as demonstrated for 5-lipoxygenase inhibition, a validated target for the treatment of inflammation and allergic reactions. Four cycles of virtual screening using both 3D- and 2D-based methods, and substructure searching were performed, and cell-based assays were used to further refine the lead selection at each stage of the process. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1535 / 1538

页数：4

共 50 条

[1] FLAVONOIDS - POTENT INHIBITORS OF ARACHIDONATE 5-LIPOXYGENASE
YOSHIMOTO, T
FURUKAWA, M
YAMAMOTO, S
HORIE, T
WATANABEKOHNO, S
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (02) : 612 - 618
[2] Substituted coumarins as potent 5-lipoxygenase inhibitors
Grimm, EL
Brideau, C
Chauret, N
Chan, CC
Delorme, D
Ducharme, Y
Ethier, D
Falgueyret, JP
Friesen, RW
Guay, J
Hamel, P
Riendeau, D
Soucy-Breau, C
Tagari, P
Girard, Y
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (09) : 2528 - 2531
[3] NOVEL SERIES OF POTENT 5-LIPOXYGENASE INHIBITORS
HITE, GA
SUAREZ, T
CHO, HL
BERTSCH, BA
TOWNER, RD
WANG, L
HO, PPK
SNYDER, DW
MIHELICH, ED
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 142 - MIDI
[4] Potent Inhibitors of 5-Lipoxygenase Identified using Pseudoreceptors
Roedl, Carmen B.
Tanrikulu, Yusuf
Wisniewska, Joanna M.
Proschak, Ewgenij
Schneider, Gisbert
Steinhilber, Dieter
Hofmann, Bettina
CHEMMEDCHEM, 2011, 6 (06) : 1001 - 1005
[5] Vitamin E metabolites as potent inhibitors of 5-lipoxygenase
Koeberle, A.
Waltenberger, B.
Temml, V
Schuster, D.
Sautebin, L.
Stuppner, H.
Richomme, P.
Werz, O.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2015, 388 : S26 - S27
[6] Scaffold-hopping of multicationic amphiphiles yields new classes of antimicrobials
Mitchell, Myles
Iannetta, Anthony
Jennings, Megan
Fletcher, Madison
Wuest, William
Minbiole, Kevin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[7] CHLOROARACHIDONIC ACIDS - POTENT AND SELECTIVE INHIBITORS OF 5-LIPOXYGENASE AND 15-LIPOXYGENASE
MUELLER, LG
OUTT, PE
GIBSON, TW
TAI, HH
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 199 : 78 - MEDI
[8] INHIBITORS OF 5-LIPOXYGENASE
BROOKS, DW
SUMMERS, JB
KERDESKY, FAJ
HOLMS, JH
MAZDIYASNI, H
RATAJCZYK, JD
DYER, RD
CARTER, GW
JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S168 - S168
[9] INHIBITORS OF 5-LIPOXYGENASE
BROOKS, DW
SUMMERS, JB
KERDESKY, FAJ
HOLMS, JH
MAZDIYASNI, H
RATAJCZYK, JD
DYER, RD
CARTER, GW
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1987, 64 (05) : 668 - 668
[10] 5-lipoxygenase inhibitors
不详
DRUG DISCOVERY TODAY, 1997, 2 (06) : 248 - 249

← 1 2 3 4 5 →