4-Amino-substituted 5-resorcinol-isoxazole derivatives, a novel class of Hsp90 inhibitor: Synthesis and evaluation of in vitro activity

被引:0
|
作者
Giannini, Giuseppe
Cabri, Walter
Brunetti, Tiziana
Ciacci, Andrea
Simoni, Daniele
Baruchello, Riccardo
Grisolia, Giuseppina
Rullo, Cinzia
Vesci, Loredana
Castorina, Massimo
Milazzo, Ferdinando Maria
Carminati, Paolo
Pisano, Claudio
机构
关键词
D O I
10.1158/1538-7445.AM10-731
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
731
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Synthesis and evaluation of the antitumor activity of 2-amino-4-tetrahy-droindazole-substituted benzamide derivatives as HSP90 inhibitors
    Jiang, Hongxiang
    Lan, Ni
    Ma, Wenhui
    Zhang, Zhuo
    Zhao, Zibo
    Hu, Yuze
    Su, Yuan
    Huang, Yunsheng
    Wang, Yifei
    Xu, Daohua
    Liu, Kaisheng
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1300
  • [2] 4-amino derivatives of the Hsp90 inhibitor CCT018159
    Barril, X
    Beswick, MC
    Collier, A
    Drysdale, MJ
    Dymock, BW
    Fink, A
    Grant, K
    Howes, R
    Jordan, AM
    Massey, A
    Surgenor, A
    Wayne, J
    Workman, P
    Wright, L
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (09) : 2543 - 2548
  • [3] Drug Design, Synthesis and In Vitro Evaluation of Substituted Benzofurans as Hsp90 Inhibitors
    Kadasi, Sundeep
    Costa, Thadeu E. M. M.
    Arukala, Neha
    Toshakani, Mallika
    Duggineti, Chaitanya
    Thota, Sreekanth
    Gupta, Sayan D.
    Raj, Shiva
    Penido, Carmen
    Henriques, Maria G.
    Raghavendra, Nulgumnalli M.
    MEDICINAL CHEMISTRY, 2018, 14 (01) : 44 - 52
  • [4] IPI-504: A novel hsp90 inhibitor with in vitro and in vivo antitumor activity
    Mitsiades, CS
    Mitsiades, N
    Rooney, M
    Negri, J
    Geer, CC
    Pink, M
    Pien, C
    Hideshima, T
    Chauhan, D
    Munshi, NC
    Richardson, PG
    Barrett, J
    Tong, JK
    Grayzel, D
    Palombella, V
    Adams, J
    Anderson, KC
    BLOOD, 2004, 104 (11) : 660A - 660A
  • [5] Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90
    Le Brazidec, JY
    Kamal, A
    Busch, D
    Thao, L
    Zhang, L
    Timony, G
    Grecko, R
    Trent, K
    Lough, R
    Salazar, T
    Khan, S
    Burrows, F
    Boehm, MF
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (15) : 3865 - 3873
  • [6] Re-screening and preliminary in vitro evaluation of resorcinol based Hsp90 inhibitors for potential protocidal activity
    Umumararungu, Theoneste
    Isaacs, Michelle
    Hoppe, Heinrich C.
    Goosen, Eleonora D.
    Khanye, Setshaba D.
    SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, 2023, 77 : 24 - 29
  • [7] Gedunin, a Novel Hsp90 inhibitor: Semisynthesis of Derivatives and Preliminary Structure-Activity Relationships
    Brandt, Gary E. L.
    Schmidt, Matthew D.
    Prisinzano, Thomas E.
    Blagg, Brian S. J.
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (20) : 6495 - 6502
  • [8] Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives
    Li, Meng
    She, Xianlan
    Ou, Yufei
    Liu, Jiangxin
    Yuan, Zaifeng
    Zhao, Qin-shi
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 244
  • [9] Synthesis and in vitro anti-HSV-1 activity of a novel Hsp90 inhibitor BJ-B11
    Ju, Huai-Qiang
    Xiang, Yang-Fei
    Xin, Bao-Juan
    Pei, Ying
    Lu, Jia-Xin
    Wang, Qiao-Li
    Xia, Min
    Qian, Chui-Wen
    Ren, Zhe
    Wang, Sha-Yan
    Wang, Yi-Fei
    Xing, Guo-Wen
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (06) : 1675 - 1677
  • [10] Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors
    Sun, Jian
    Lin, Cai
    Qin, Xiaochu
    Dong, Xiaoping
    Tu, Zhengchao
    Tang, Fei
    Chen, Chaonan
    Zhang, Jiancun
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (16) : 3129 - 3134