Survival outcomes after breast-conserving surgery plus radiotherapy compared with mastectomy in breast ductal carcinoma in situ with microinvasion

被引:3
|
作者
Xia, Lin-Yu [1 ]
Xu, Wei-Yun [2 ]
Hu, Qing-Lin [1 ]
机构
[1] Chengdu Med Coll, Affiliated Hosp 1, Dept Thyroid & Breast Surg, 278 Baoguang Ave Middle Sect, Chengdu 610500, Sichuan, Peoples R China
[2] Mianyang Cent Hosp, Dept Breast Surg, Mianyang, Sichuan, Peoples R China
关键词
LONG-TERM OUTCOMES; 20-YEAR FOLLOW-UP; CANCER; WOMEN; LUMPECTOMY; MANAGEMENT; PROGNOSIS; FEATURES; IMPACT; RISK;
D O I
10.1038/s41598-022-24630-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ductal carcinoma in situ with microinvasion (DCIS-MI) is a subtype of breast cancer with a good prognosis, for which both breast conserving surgery plus radiotherapy (BCS + RT) and mastectomy are feasible surgical methods, but no clear conclusion has been made on the choice of these treatments. We used the Surveillance, Epidemiology and End Results database to extract 5432 DCIS-MI patients. Participants were divided into the BCS + RT group and the mastectomy group. We compared the overall survival (OS) and breast cancer-specific survival (BCSS) of the two groups using the Kaplan-Meier method and Cox regressions before and after propensity score matching (PSM). Before PSM, both univariate and multivariate analyses showed that BCS + RT group had significantly higher OS and BCSS compared with patients in the mastectomy group (P < 0.001). After PSM, the multivariate analysis showed that compared with mastectomy, the BCS + RT showed significantly higher OS and BCSS (HR = 0.676, 95% CI = 0.540-0.847, P < 0.001; HR = 0.565,95% CI = 0.354-0.903, P = 0.017). In addition, the subgroup analysis showed that BCS + RT is at least equivalent to mastectomy with respect to OS and BCSS in any subgroup. For patients with DCIS-MI, the prognosis of BCS + RT was superior to mastectomy.
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页数:10
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