Chemokines and chemokine receptors: an overview

被引：194
|
作者：
Bonecchi, Raffaella [1 ,2 ]
Galliera, Emanuela [2 ]
Borroni, Elena M. [1 ,2 ]
Corsi, Massimiliano M. [2 ]
Locati, Massimo [1 ,2 ]
Mantovani, Alberto [1 ,2 ]
机构：
[1] Ist Clin Humanitas, IRCCS, I-20089 Rozzano, Italy
[2] Univ Milan, Fac Med, Inst Gen Pathol, I-20133 Milan, Italy
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2009年 / 14卷
关键词：
Chemokine; Chemokine Receptor; Inflammation; Review; CUTTING EDGE; CC-CHEMOKINE; IMMUNE-RESPONSE; CXC CHEMOKINES; D6; INFLAMMATION; EXPRESSION; DECOY; SYSTEM; CANCER;
D O I：
10.2741/3261
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.
引用
收藏
页码：540 / 551
页数：12
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