Ankle brachial index and cognitive function among Hispanics/Latinos: Results from the Hispanic Community Health Study/Study of Latinos

被引:9
|
作者
Tarraf, Wassim [1 ,2 ]
Criqui, Michael H. [3 ]
Allison, Matthew A. [4 ]
Wright, Clinton B. [5 ]
Fornage, Myriam [6 ]
Daviglus, Martha [7 ]
Kaplan, Robert C. [8 ]
Davis, Sonia [9 ]
Conceicao, Alan S. [10 ]
Gonzalez, Hector M. [11 ,12 ]
机构
[1] Wayne State Univ, Inst Gerontol, 87 East Ferry St,240 Knapp Bldg, Detroit, MI 48202 USA
[2] Wayne State Univ, Dept Hlth Care Sci, 87 East Ferry St,240 Knapp Bldg, Detroit, MI 48202 USA
[3] Univ Calif San Diego, Family & Preventat Med, 9500 Gilman Dr,MC 0607,SCRB 352, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Family & Preventat Med, 9500 Gilman Dr,MC 0965, La Jolla, CA 92093 USA
[5] NINDS, Div Clin Res, NIH, 6001 Execut Blvd,Suite 3309, Bethesda, MD 20892 USA
[6] Univ Texas Hlth Sci Ctr Houston, 1825 Pressler St,Bldg SRB 530G, Houston, TX 77030 USA
[7] Univ Illinois, Feinberg Sch Med, Dept Preventat Med, 1819 W Polk St,MC 764,Suite 246, Chicago, IL 60612 USA
[8] Albert Einstein Coll Med, Epidemiol & Populat Hlth, 1300 Morris Pk Ave,Belfer Bldg,Room 1306C, Bronx, NY 10461 USA
[9] Univ N Carolina, Dept Biostat, 137 East Franklin St,Suite 203, Chapel Hill, NC 27514 USA
[10] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA
[11] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[12] Univ Calif San Diego, Shiley Marcos Alzheimers Dis Res Ctr, La Jolla, CA 92093 USA
关键词
Cognition; Ankle-brachial index; Atherosclerosis; ABI; Peripheral arterial disease; Cardiovascular health; Hispanics; Latinos; Epidemiology; AMERICAN-HEART-ASSOCIATION; NEUROCOGNITIVE FUNCTION; CARDIOVASCULAR-DISEASE; ARTERIAL STIFFNESS; UNITED-STATES; RISK-FACTORS; IMPAIRMENT; POPULATION; STROKE; DEMENTIA;
D O I
10.1016/j.atherosclerosis.2018.02.016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aims: The Ankle-Brachial index (ABI) is a well-accepted measure of peripheral artery disease (arterial stenosis and stiffness) and has been shown to be associated with cognitive function and disorders; however, these associations have not been examined in Hispanics/Latinos. Therefore, we sought to examine relationships between ABI and cognitive function among diverse middle-age and older Hispanics/Latinos. Methods: We used cross-sectional data on n = 7991 participants aged 45-74 years, without stroke or coronary heart disease, from the Hispanic Community Health Study/Study of Latinos. Our primary outcome, global cognition (GC), was a continuous composite score of four cognitive domains (verbal learning and memory, verbal fluency, executive function, and mental status). Secondary outcomes were the individual tests representing these domains. The ABI was analyzed continuously and categorically with standard clinical cut-points. We tested associations using generalized survey regression models incrementally adjusting for confounding factors. Age, sex, hypertension, diabetes, and dyslipidemia moderations were examined through interactions with the primary exposure. Results: In age, sex, and education adjusted models, continuous ABI had an inverse u-shape association with worse GC. We found similar associations with measures of verbal learning and memory, verbal fluency, executive function, but not with low mental status. The associations were attenuated, but not completely explained, by accounting for the confounders and not modified by age, sex, education, and vascular disease risks. Conclusions: In addition to being a robust indicator of arterial compromise, our study suggests that abnormal ABI readings may also be useful for early signaling of subtle cognitive deficits. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:61 / 69
页数:9
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