Mechanism and specificity of RNA cleavage by chemical ribonucleases.

被引：7
|
作者：
Beloglazova, N
Vlassov, A
Konevetc, D
Sil'nikov, V
Zenkova, M
Giege, R
Vlassov, V
机构：
[1] Russian Acad Sci, Inst Bioorgan Chem, Novosibirsk 630090, Russia
[2] CNRS, Inst Biol Mol & Cellulaire, Strasbourg, France
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期
关键词：
D O I：
10.1080/07328319908044753
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cleaving of model RNA substrates by chemical ribonucleases constructed by conjugation of 1,4 diazabicyclo[2,2,2]octane with histamine and histidine was investigated. Similarly to RNase A, the chemical RNases produce fragments with 5' hydroxy-group and 3'-cyclophosphate. The cleavage occurs as the catalytic reaction: more than 150 phosphodiester bonds in RNA can be cleaved by one molecule of RNase mimic.
引用
收藏
页码：1463 / 1465
页数：3
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