Poliovirus: New insights from an old paradigm

被引：30
|
作者：
Wien, MW
Chow, M
Hogle, JM
机构：
[1] HARVARD UNIV,COMM HIGHER DEGREES BIOPHYS,CAMBRIDGE,MA 02138
[2] UNIV ARKANSAS MED SCI HOSP,DEPT MICROBIOL & IMMUNOL,LITTLE ROCK,AR 72205
[3] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115
来源：
STRUCTURE | 1996年 / 4卷 / 07期
关键词：
D O I：
10.1016/S0969-2126(96)00082-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A combination of structural and genetic studies of poliovirus suggests that the final stages of viral assembly lock the virus in a metastable structure primed to undergo the receptor-catalyted conformational changes required for cell entry. Future studies promise to provide detailed insights into the conformational dynamics of the virion during its life cycle.
引用
收藏
页码：763 / 767
页数：5
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