Research Advances of KRN7000 Analogues and Their Immune Activities

被引：2
|
作者：
Feng, Junna [1 ,2 ]
Gao, Fang [1 ]
Peng, Shaohui [2 ]
Chen, Hua [1 ]
Li, Xiaoliu [1 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
[2] China Univ Geosci, Great Wall Coll, Baoding 071000, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 35卷 / 05期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
KRN7000; immunomodulator; T(H)1/T(H)2; ALPHA-GALACTOSYL CERAMIDE; KILLER T-CELLS; BIOLOGICAL-ACTIVITY; MOUSE LYMPHOCYTES; C-GLYCOSIDE; ASYMMETRIC EPOXIDATION; HYDROXYLATED ANALOGS; CONCISE SYNTHESIS; PHASE-I; ACTIVATION;
D O I：
10.6023/cjoc201409048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
KRN7000 has widely biological activities, such as anti-tumor, anti-tuberculosis, anti-fungal, anti-virus, anti-inflammation, and against auto-immune diseases. As the potential immunomodulator, KRN7000 can effectively activate the natural killer T cells (NKT cells) and induce the secretion of IFN-gamma and IL-4 cytokines. However, IFN-gamma inhibited the activity of T helper 2 cells (T(H)2) and IL-4 inhibited the activity of T helper 1 cells (T(H)1), which mediated humoral as well as celluar immune reactions, respectively. The concomitant of functions of T(H)1 and T(H)2 limits the therapeutic potential of KRN7000 against immune diseases. Therefore, developing new analogues of KRN7000 to find new immnostimulating drugs has drawn many attentions in the world. This review presents the recent progress in the study on the structure and immune activity of the synthesized KRN7000 derivatives.
引用
收藏
页码：997 / 1008
页数：12
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