Application of the intravenous glucose tolerance test and the minimal model to patients with insulinoma: insulin sensitivity (Si) and glucose effectiveness (Sg) before and after surgical excision

被引：2

作者：

Vethakkan, S. R. ^{[1
]}

Walters, J. M. ^{[2
]}

Gooley, J. L. ^{[2
]}

Boston, R. C. ^{[3
]}

Ward, G. M. ^{[1
,2
,4
]}

机构：

[1] St Vincents Hlth Melbourne, Dept Endocrinol & Diabet, Melbourne, Vic, Australia

[2] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia

[3] Univ Penn, New Bolton Ctr, Kennett Sq, PA USA

[4] St Vincents Hlth, Dept Clin Chem, Melbourne, Vic, Australia

来源：

CLINICAL ENDOCRINOLOGY | 2009年 / 70卷 / 01期

关键词：

DIABETES-MELLITUS; HYPOGLYCEMIA; SECRETION; DISPOSAL; VALUES; TUMORS;

D O I：

10.1111/j.1365-2265.2008.03287.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The unmodified frequently sampled intravenous glucose tolerance test (FSIGT) has not previously been used to assess insulin/glucose kinetics in patients with insulinoma. To measure insulin sensitivity (Si) and glucose effectiveness (Sg) by means of the FSIGT in patients with insulinoma, before and after surgical removal of the tumour. FSIGTs were performed in five patients, before and approximately 3 months post-surgery, and in 11 controls. Si and Sg were estimated using Minimal Model computer analysis of dynamic glucose and insulin data. Si was lower in insulinoma patients before, compared with after surgery (3.37 +/- 0.62 vs. 6.24 +/- 1.09 SE [x10(-4)] min(-1)mu U(-1) ml, P < 0.05). Sg was similar in patients pre- and post-surgery (3.0 +/- 0.67 vs. 2.4 +/- 0.6 [x10(-2)] min(-1), NS). Insulin sensitivity improves after excision of an insulinoma. Glucose effectiveness is not influenced by chronic hyperinsulinaemia and hypoglycaemia.

引用

页码：47 / 52

页数：6

共 50 条

[1] The intravenous prandial glucose tolerance test (IVPGTT) minimal model for measuring glucose effectiveness and insulin sensitivity.
Simeoni, M
Basu, A
Caumo, A
Rizza, A
Cobelli, C
[J]. DIABETOLOGIA, 1999, 42 : A186 - A186
[2] The intravenous prandial glucose tolerance test (IVPGTT) to measure glucose effectiveness and insulin sensitivity with the minimal models
Simeoni, M
Basu, A
Caumo, A
Rizza, RA
Cobelli, C
[J]. DIABETES, 1999, 48 : A288 - A288
[3] Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test
Aloulou, K
Brun, JF
Mercier, J
[J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (05): : 676 - 690
[4] Repeatability of insulin sensitivity and glucose effectiveness from minimal model analysis of the frequently-sampled intravenous glucose tolerance test in horses.
不详
[J]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2005, 19 (03) : 484 - 484
[5] Generalized sensitivity analysis of the minimal model of the intravenous glucose tolerance test
Munir, Mohammad
[J]. MATHEMATICAL BIOSCIENCES, 2018, 300 : 14 - 26
[6] INSULIN SENSITIVITY AND GLUCOSE CLEARANCE QUANTIFIED IN HUMANS FROM LABELED INTRAVENOUS GLUCOSE-TOLERANCE TEST AND MINIMAL MODEL
CAUMO, A
GIACCA, A
MORGESE, M
RIVOLTA, G
POZZA, G
MICOSSI, P
COBELLI, C
[J]. DIABETOLOGIA, 1987, 30 (07) : A506 - A506
[7] Minimal model (MM) for oral glucose tolerance test: Validation of insulin sensitivity index (SI) estimation and application to multiethnic population
Rovetti, Robert J.
Chu, Roy
Landaw, Elliot M.
Ipp, Eli
[J]. DIABETES, 2006, 55 : A566 - A566
[8] MINIMAL MODEL ANALYSIS OF INTRAVENOUS GLUCOSE-TOLERANCE TEST-DERIVED INSULIN SENSITIVITY IN DIABETIC SUBJECTS
WELCH, S
GEBHART, SSP
BERGMAN, RN
PHILLIPS, LS
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 71 (06): : 1508 - 1518
[9] Prediction of the Minimal Model insulin sensitivity index through one hour intravenous glucose tolerance test data
Tura, A.
Sbrignadello, S.
Pacini, G.
[J]. DIABETOLOGIA, 2008, 51 : S280 - S280
[10] A simple intravenous glucose tolerance test for assessment of insulin sensitivity
Hahn, Robert G.
Ljunggren, Stefan
Larsen, Filip
Nystrom, Thomas
[J]. THEORETICAL BIOLOGY AND MEDICAL MODELLING, 2011, 8

← 1 2 3 4 5 →