Neoadjuvant Therapy for Potentially Resectable Pancreatic Cancer: An Emerging Paradigm?

被引：8
|
作者：
Brunner, Thomas B. [1 ,2 ]
机构：
[1] Univ Freiburg, Dept Radiat Oncol, D-79106 Freiburg, Germany
[2] Univ Oxford, Dept Oncol, Gray Inst Radiat Oncol & Biol, Oxford, England
来源：
CURRENT ONCOLOGY REPORTS | 2013年 / 15卷 / 02期
关键词：
Pancreatic cancer; Neoadjuvant chemoradiotherapy; Potentially resectable; Borderline resectable; PHASE-II TRIAL; INTRAOPERATIVE RADIATION-THERAPY; PREOPERATIVE CHEMORADIATION; RESPONSE EVALUATION; ADENOCARCINOMA; CHEMORADIOTHERAPY; CARCINOMA; OUTCOMES; PANCREATICODUODENECTOMY; CHEMOTHERAPY;
D O I：
10.1007/s11912-012-0291-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although neoadjuvant chemoradiotherapy has been tested for more than two decades and can be safely delivered to patients with non-metastatic pancreatic cancer, no randomised trials have been reported until now. Here we provide an overview of the first randomised trial in patients with potentially resectable cancer and of the latest developments in neoadjuvant therapy for this group of patients. It is necessary to continue to perform clinical trials in this field to accurately identify the effect on survival and quality of life in patients with potentially resectable, borderline resectable and unresectable pancreatic cancer. Aspects of imaging for restaging and clinical prognostic factors are also discussed given they will be useful instruments for future trials.
引用
收藏
页码：162 / 169
页数：8
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