Chemoenzymatic synthesis of (4S,5R)-5-hydroxy-γ-decalactone

被引：21
|
作者：
Fadnavis, NW [1 ]
Vadivel, SK [1 ]
Sharfuddin, M [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem 1, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 19期
关键词：
D O I：
10.1016/S0957-4166(99)00411-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Reduction of ethyl 2-hydroxy-3-oxooctanoate with immobilised baker's yeast at pH 4.0 yields anti-2R,3R-dihydroxy ester with high diastereoselectivity and enantioselectivity (de 70%, ee 80%) which is conveniently converted to (4S,5R)-5-hydroxy-gamma-decalactone. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3675 / 3680
页数：6
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