Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease

被引：23
|
作者：
Liu, HC [1 ]
Hong, CJ
Liu, CY
Lin, KN
Tsai, SJ
Liu, TY
Chi, CW
Wang, PN
机构：
[1] Taipei Vet Gen Hosp, Inst Neurol, Taipei, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[3] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan
[4] Chang Gung Univ Sch Med, Dept Psychiat, Taoyuan, Taiwan
[5] Chang Gung Mem Hosp, Taoyuan, Taiwan
[6] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan
来源：
PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2001年 / 55卷 / 04期
关键词：
Alzheimer's disease; depression; polymorphism; serotonin receptor 6 gene;
D O I：
10.1046/j.1440-1819.2001.00886.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A significant increase of 267C allele of the 5-HT6 receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers fur evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT6 genotype or allele distributions between the AD patients with depressive disorders (n=25) and those without (n=120) was not significant.
引用
收藏
页码：427 / 429
页数：3
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