The progressive collapse of the frame structure is simulated with testing a 1/3 scale, 4x2-bay and 3-storey reinforced concrete spatial frame in this paper. The experimental model was designed according to the non-seismic resistance demand, and the middle-side column of the bottom floor was replaced by a mechanical jack to simulate its initial local damage. Based on the experimental results, the applied load process and the load transferring mechanism of the model frame are analyzed. The progressive collapse-resisting performance of reinforced concrete frames with non-seismic demand are obtained.