Photo-induced antimicrobial and DNA cleavage studies of indoloquinolines and 1,8-naphtharidine

被引：5

作者：

Mahalingam, Malathi ^{[1
]}

Mohan, Palathurai Subramaniam ^{[1
]}

Gayathri, Kasirajan ^{[1
]}

Gomathi, Ramadoss ^{[1
]}

Subhapriya, Pushparaja ^{[2
]}

机构：

[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India

[2] Bannari Amman Inst Technol, Dept Chem, Sathyamangalam 638401, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2013年 / 125卷 / 05期

关键词：

Vilsmeier-Haack reagent; indoloquinolines; photosensitizer; photoinduced antibacterial activity; photo-DNA binding; BINDING PROPERTIES; DERIVATIVES; SERIES; PHOTOINACTIVATION; PHOTOSENSITIZERS; PHTHALOCYANINE; PORPHYRIN; DESIGN; DYE;

D O I：

10.1007/s12039-013-0486-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Angular and linear isomers of indoloquinoline are synthesized from 4-hydroxyquinolin-2(1H)-one. The use of Vilsmeier-Haack reagent on N-phenylpropionamide yielded a new versatile method for the synthesis of 2-chloro-3-methylquinoline which is utilized as precursor in the synthesis of basic camptothecin core and quinoline fused with 1,8-naphthridine. The in vivo photoinduced antibacterial activity of all the synthesized compounds has been studied. The unique photo-bioactivity of 5H-indolo[3,2-c]quinolin-6(11H)-one is further studied under the photo-DNA cleavage analysis. Theoretical calculations for the synthesized compounds are performed to determine further credentials of the biological results.

引用

页码：1015 / 1027

页数：13

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