A Novel Synthetic Method of 5-Aminolevulinic Acid Hydrochloride

被引：3
|
作者：
Chi, Pengli [1 ]
Xie, Cuiyue [1 ]
Lin, Jimao [1 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 03期
关键词：
epichlorohydrin; 5-aminolevulinic acid hydrochloride; synthesis;
D O I：
10.6023/cjoc201210005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, a novel synthetic method of 5-aminolevulinic acid (5-ALA) hydrochloride was described starting from cheap and easily available epichlorohydrin. The 5-aminolevulinic acid hydrochloride was obtained by Gabriel reaction, ring-opening, oxidation, substitution and hydrolysis. The results showed that the synthetic method has the advantages of materials being simply available, good overall yield, easily work-up and low cost.
引用
下载
收藏
页码：640 / 642
页数：3
相关论文
共 9 条
  • [1] Ahmed K., 2007, J MOL CATAL B-ENZYM, V47, P1
  • [2] Chan C.-C., 1982, SYNTHETIC COMMUN, V6, P452
  • [3] SELECTIVE BROMINATION OF KETONES - A CONVENIENT SYNTHESIS OF 5-AMINOLEVULINIC ACID
    HA, HJ
    LEE, SK
    HA, YJ
    PARK, JW
    [J]. SYNTHETIC COMMUNICATIONS, 1994, 24 (18) : 2557 - 2562
  • [4] Liu HL, 2005, CHINESE J ORG CHEM, V25, P1431
  • [5] Efficient Horner-Wadsworth-Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones
    Pace, Vittorio
    Martinez, Fernando
    Nova, Clara I.
    Fernandez, Maria
    Vicente Sinisterra, Jose
    Alcantara, Andres R.
    [J]. TETRAHEDRON LETTERS, 2009, 50 (25) : 3050 - 3053
  • [6] Synthesis and Structure Elucidation of New Spiro Compounds with Polyfluoroalkyl and Phosphonate Ester Groups
    Shi, Zhijian
    Zhao, Yang
    Cao, Weiguo
    Zhang, Shunli
    Liu, Mei
    [J]. SYNTHETIC COMMUNICATIONS, 2009, 39 (08) : 1494 - 1503
  • [7] Preparation of [1,2,3,4,5-13C5]-5-amino-4-oxopentanoic acid (ALA) -: Design of a synthetic scheme to prepare any 13C- and 15N-isotopomer with high isotopic enrichment
    Shrestha-Dawadi, PB
    Lugtenburg, J
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (23) : 4654 - 4663
  • [8] YOUSIF MM, 1982, CHEM PHARM BULL, V30, P1680
  • [9] Zhang Y.-X., 2001, J HENAN MED U, V36, P599
1