Metallo-β-lactamase:: structure and mechanism

被引：263

作者：

Wang, ZG ^{[1
]}

Fast, W ^{[1
]}

Valentine, AM ^{[1
]}

Benkovic, SJ ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(99)00017-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.

引用

页码：614 / 622

页数：9

共 50 条

[1] Metallo-β-lactamase structure and function
Palzkill, Timothy
[J]. ANTIMICROBIAL THERAPEUTICS REVIEWS: THE BACTERIAL CELL WALL AS AN ANTIMICROBIAL TARGET, 2013, 1277 : 91 - 104
[2] Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase
Softley, Charlotte A.
Zak, Krzysztof M.
Bostock, Mark J.
Fino, Roberto
Zhou, Richard Xu
Kolonko, Marta
Mejdi-Nitiu, Ramona
Meyer, Hannelore
Sattler, Michael
Popowicz, Grzegorz M.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (06)
[3] On the mechanism of the metallo-β-lactamase from Bacteroides fragilis
Wang, ZG
Fast, W
Benkovic, SJ
[J]. BIOCHEMISTRY, 1999, 38 (31) : 10013 - 10023
[4] Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic
Khrenova M.G.
Kulakova A.M.
Grigorenko B.L.
Nemukhin A.V.
[J]. Moscow University Chemistry Bulletin, 2018, 73 (4) : 155 - 157
[5] The Continuing Challenge of Metallo-β-Lactamase Inhibition: Mechanism Matters
Ju, Lin-Cheng
Cheng, Zishuo
Fast, Walter
Bonomo, Robert A.
Crowder, Michael W.
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2018, 39 (07) : 635 - 647
[6] Inhibition of bacterial metallo-β-lactamase
Shaw, RW
Kim, SK
[J]. FASEB JOURNAL, 2003, 17 (05): : A981 - A981
[7] Novel metallo-β-lactamase inhibitors
Hofer U.
[J]. Nature Reviews Microbiology, 2022, 20 (3) : 125 - 125
[8] Catalytic mechanism of class B2 metallo-β-lactamase
Xu, DG
Xie, DQ
Guo, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (13) : 8740 - 8747
[9] Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism
Palacios, Antonela R.
Rossi, Maria-Agustina
Mahler, Graciela S.
Vila, Alejandro J.
[J]. BIOMOLECULES, 2020, 10 (06)
[10] Epidemiology of extended-spectrum β-lactamase/metallo-β-lactamase
Migliavacca, R.
Balzaretti, M.
Nucleo, E.
D'Andrea, M. M.
Mugnaioli, C.
Spalla, M.
Giani, T.
Rossolini, G. M.
Pagani, L.
[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 : S90 - S90

← 1 2 3 4 5 →