Antifungal resistance Sterol homeostasis in yeast

被引：4
|
作者：
Rogers, P. David [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Pharm & Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA
来源：
NATURE CHEMICAL BIOLOGY | 2022年 / 18卷 / 11期
关键词：
TRANSCRIPTION FACTOR UPC2P; UP-REGULATION; MUTATIONS;
D O I：
10.1038/s41589-022-01143-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The fungal sterol receptor and transcription factor Upc2 activates the transcription of ergosterol biosynthesis genes in response to ergosterol depletion in yeast. A structural and biochemical study reveals an Hsp90-dependent translocation activation mechanism of Upc2, with implications for triazole antifungal resistance.
引用
收藏
页码：1170 / 1171
页数：2
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