Aminoglycoside-modifying enzymes

被引：181
|
作者：
Wright, GD [1 ]
机构：
[1] McMaster Univ, Dept Biochem, Antimicrobial Res Ctr, Hamilton, ON L8N 3Z5, Canada
来源：
CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 05期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S1369-5274(99)00007-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bacterial resistance to the aminoglycoside antibiotics is most frequently associated with the expression of modifying enzymes that can phosphorylate, adenylate or acetylate these compounds. The recent availability of representative crystal structures for all three classes of modifying enzymes has greatly expanded our knowledge of enzyme function, and has revealed unexpected and exciting connections to other families of enzymes. Furthermore, the complete genome sequences for several bacteria have revealed many potential aminoglycoside-resistance elements.
引用
收藏
页码：499 / 503
页数：5
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