Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and their cellular response
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作者:
Zhang, Qingchun
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E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Zhang, Qingchun
[1
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Jiang, Yun
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Lib Zhejiang Univ Technol, Hangzhou 310023, Zhejiang, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Jiang, Yun
[2
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Zhang, Yan
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E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Zhang, Yan
[1
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Ye, Zhaoyang
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E China Univ Sci & Technol, Sch Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Ye, Zhaoyang
[3
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Tan, Wensong
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E China Univ Sci & Technol, Sch Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Tan, Wensong
[3
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Lang, Meidong
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E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
Lang, Meidong
[1
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机构:
[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
[2] Lib Zhejiang Univ Technol, Hangzhou 310023, Zhejiang, Peoples R China
[3] E China Univ Sci & Technol, Sch Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
Porous poly(epsilon-caprolactone) (PCL) scaffolds are widely used as in vivo implants in tissue engineering, and their long-term degradation behaviors are of great importance for their in vivo performances. However, the influence of porosity on long-term degradation of PCL scaffold in phosphate buffer solution (PBS) has been rarely reported so far. Herein, a 72-week degradation study of PCL scaffolds with various porosities was conducted to elucidate the changes of physico-chemical properties such as weight, molecular weight, morphology and compressive modulus. Within 72 weeks, PCL scaffolds experienced three stages: stable stage, mechanical loss stage and structural collapse stage. The higher porosity induced the severer loss of weight, molecular weight and compressive modulus. It was found that a minimal acid autocatalysis also happened in the scaffold samples with low porosities (less than 85%). Cellular response on the scaffolds with various porosities was further evaluated. The cell ingrowth improved on the scaffold with high porosity (e.g. S-10) in contrast to those with low porosity (e.g. S-6 and S-4). The combined results demonstrated that an optimal porosity of PCL scaffolds should be designed greater than 90% due to the appropriate degradation rate and good cell performance. (C) 2012 Elsevier Ltd. All rights reserved.
机构:
Res Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Lab Plast & Rubber Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Hegyesi, Nora
Hodosi, Elek
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Res Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Lab Plast & Rubber Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Hodosi, Elek
Polyak, Peter
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Res Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Lab Plast & Rubber Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Polyak, Peter
Faludi, Gabor
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Res Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Lab Plast & Rubber Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Faludi, Gabor
Balogh-Weiser, Diana
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Budapest Univ Technol & Econ, Dept Organ Chem & Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Balogh-Weiser, Diana
Pukanszky, Bela
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机构:
Res Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary
Budapest Univ Technol & Econ, Dept Phys Chem & Mat Sci, Lab Plast & Rubber Technol, POB 91, H-1521 Budapest, HungaryRes Ctr Nat Sci, Inst Mat & Environm Chem, POB 286, H-1519 Budapest, Hungary