New Prolinamides with Isosteviol Skeleton as Efficient Organocatalysts for the Direct Asymmetric Aldol Reaction

被引：3
|
作者：
Liu, Yu-Xia [1 ]
Ma, Zhi-Wei [3 ]
Li, Yan-Xun [1 ]
Tao, Jing-Chao [2 ]
机构：
[1] Henan Inst Engn, Dept Mat & Chem Engn, Zhengzhou 450007, Henan, Peoples R China
[2] Zhengzhou Univ, Dept Chem, New Drug Res & Dev Ctr, Zhengzhou 450052, Henan, Peoples R China
[3] Henan Univ Anim Husb & Econ, Dept Fundamental Courses, Zhengzhou 450044, Henan, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2018年 / 15卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Aldol reaction; asymmetric catalysis; isosteviol; organocatalyst; prolinamide; synthesis; 3-COMPONENT MANNICH REACTIONS; MICHAEL ADDITION; STEREOSELECTIVE-SYNTHESIS; AQUEOUS-MEDIUM; WATER; DERIVATIVES; CATALYSIS; ALDEHYDES; KETONES; ISOBUTYRALDEHYDE;
D O I：
10.2174/1570178615666171226163338
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, two new prolinamides with isosteviol skeleton were synthesized and used as chiral catalysts for the asymmetric aldol reaction. Solvent effects, catalyst loading, substrate scope and the influence of water on the reaction were investigated. With only 5 mol % loading, the synthesized catalysts showed excellent activity (up to 98% yield) and good stereoselectivity (up to 87:13 dr, 90% ee) for the direct aldol reaction of cyclohexanone and substituted benzaldehydes at room temperature.
引用
收藏
页码：307 / 313
页数：7
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