Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

被引：35
|
作者：
Smemo, S
Nowotny, P
Hinrichs, AL
Kauwe, JSK
Cherny, S
Erickson, K
Myers, AJ
Kaleem, M
Marlowe, L
Gibson, AM
Hollingworth, P
O'Donovan, MC
Morris, CM
Holmans, P
Lovestone, S
Morris, JC
Thal, L
Li, YH
Grupe, A
Hardy, J
Owen, MJ
Williams, J
Goate, A
机构：
[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[2] NIA, Bethesda, MD 20892 USA
[3] Newcastle Univ, Newcastle Gen Hosp, Inst Hlth & Aging, Newcastle Upon Tyne, Tyne & Wear, England
[4] Cardiff Univ, Sch Med, Dept Med Psychol, Cardiff, Wales
[5] Cardiff Univ, Biostat & Bioinformat Unit, Cardiff, Wales
[6] Kings Coll London, Inst Psychiat, London, England
[7] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[8] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA
[9] Celera Diagnost, Alameda, CA USA
[10] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
来源：
ANNALS OF NEUROLOGY | 2006年 / 59卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1002/ana.20673
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.
引用
收藏
页码：21 / 26
页数：6
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