Unexpected Autocrine Role of Vascular Endothelial Growth Factor in Squamous Cell Carcinoma

被引：1

作者：

Arbiser, Jack L. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 03期

关键词：

HUMAN CANCER-CELLS; SIGNAL-TRANSDUCTION; VEGF RECEPTORS; IN-VIVO; ANGIOSARCOMA; BEVACIZUMAB; TUMORIGENESIS; ANGIOGENESIS; EXPRESSION; APOPTOSIS;

D O I：

10.1038/jid.2008.427

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mirones et al. demonstrate that keratinocytes deficient in VEGF are capable of forming tumors but use a distinct form of aneuploidy and signaling to form tumors. This knowledge is important because inhibitors of VEGF, including bevacizumab (anti-VEGF antibodies) and sorafenib (Braf/VEGFR2 kinase inhibitor), have already entered the clinic. These agents may "remodel" tumor signaling.

引用

页码：538 / 540

页数：3

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