Plasma nevirapine levels and 24-week efficacy in HIV-infected patients receiving nevirapine-based highly active antiretroviral therapy with or without rifampicin

被引：43
|
作者：
Manosuthi, Weerawat
Sungkanuparph, Somnuek
Thakkinstian, Ammarin
Rattanasiri, Sasivimol
Chaovavanich, Achara
Prasithsirikul, Wisit
Likanonsakul, Sirirat
Ruxrungtham, Kiat
机构：
[1] Bamrasnaradura Infect Dis Inst, Dept Med, Minist Publ Hlth, Nonthaburi 110001, Thailand
[2] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok 10700, Thailand
[3] Mahidol Univ, Ramathibodi Hosp, Clin Epidemiol Unit, Bangkok 10700, Thailand
[4] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand
来源：
CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 02期
关键词：
D O I：
10.1086/505210
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Seventy human immunodeficiency virus ( HIV) -infected patients receiving rifampicin and 70 HIV-infected patients not receiving rifampicin were enrolled to receive 400 mg of nevirapine-based highly active antiretroviral therapy per day. Mean plasma nevirapine levels at 8 and 12 weeks were lower in patients receiving rifampicin ( P = .048). However, viro. 048 logical and immunological outcomes at 24 weeks were not different between the 2 groups ( P > .05).
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页码：253 / 255
页数：3
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