Advances in mRNA Vaccines for Infectious Diseases

被引：430
|
作者：
Zhang, Cuiling [1 ]
Maruggi, Giulietta [2 ]
Shan, Hu [1 ]
Li, Junwei [1 ]
机构：
[1] Qingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China
[2] GSK, Rockville, MD USA
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
关键词：
mRNA vaccine; infectious disease; delivery; mechanism; application; DOUBLE-STRANDED-RNA; INFLUENZA-A VIRUS; INNATE IMMUNE-RESPONSES; T-CELL RESPONSES; NF-KAPPA-B; DENDRITIC CELLS; RIG-I; PROTECTIVE EFFICACY; NONVIRAL DELIVERY; DNA VACCINES;
D O I：
10.3389/fimmu.2019.00594
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During the last two decades, there has been broad interest in RNA-based technologies for the development of prophylactic and therapeutic vaccines. Preclinical and clinical trials have shown that mRNA vaccines provide a safe and long-lasting immune response in animal models and humans. In this review, we summarize current research progress on mRNA vaccines, which have the potential to be quick-manufactured and to become powerful tools against infectious disease and we highlight the bright future of their design and applications.
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页数：13
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