The Impact of Tumor Necrosis Factor-α and Interleukin-1β Levels and Polymorphisms on Long-Term Stroke Outcomes

Background: The accuracy of predictions regarding disability that sets in after stroke could be improved by using blood biomarker measurements. This study aimed to investigate the roles of serum tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta concentrations and polymorphisms in stroke outcomes. Methods: In total, 286 patients were evaluated at the time of admission and at 2 weeks after stroke, and 222 of these patients (78%) were followed up for 1 year to evaluate the consequences of stroke during both the acute and chronic stages. Stroke outcomes were dichotomized into good and poor using the modified Rankin Scale. Results: The association of TNF-alpha and IL-1 beta concentrations and their corresponding genotypes with stroke outcomes was investigated using multivariate logistic regression. Higher TNF-alpha levels were associated with poor outcomes 1 year after stroke in the presence of the -850T and -308A alleles, and IL-1 beta levels were associated with poor 1-year stroke outcomes in the presence of the -511T and +3953T alleles. No such associations were found at 2 weeks after stroke. Conclusions: These data provide evidence that serum TNF-alpha and IL-1 beta concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles. (C) 2017 S. Karger AG, Basel