Bioactive Carbazole Alkaloids from Clausena wallichii Roots

被引：148
|
作者：
Maneerat, Wisanu [1 ]
Ritthiwigrom, Thunwadee [2 ]
Cheenpracha, Sarot [3 ]
Promgool, Trinop [1 ]
Yossathera, Kulsiri [1 ]
Deachathai, Suwanna [1 ]
Phakhodee, Wong [1 ]
Laphookhieo, Surat [1 ]
机构：
[1] Mae Fah Luang Univ, Sch Sci, Nat Prod Res Lab, Muang 57100, Chiang Rai, Thailand
[2] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand
[3] Univ Phayao, Sch Sci, Muang 56000, Phayao, Thailand
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期
关键词：
STRUCTURAL ELUCIDATION; CHEMICAL-CONSTITUENTS; EXCAVATA; ISOLATION;
D O I：
10.1021/np3000365
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 mu g/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC50 values of 10.2 and 4.5 mu M, respectively.
引用
收藏
页码：741 / 746
页数：6
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