Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease

被引：39
|
作者：
Tarragon, Ernesto [1 ,2 ,3 ]
Lopez, Dolores [3 ]
Estrada, Cristina [1 ,2 ]
Ana, Gonzalez-Cuello [3 ]
Schenker, Esther [4 ]
Pifferi, Fabien [5 ]
Bordet, Regis [6 ]
Richardson, Jill C. [7 ]
Trinidad Herrero, Maria [1 ,2 ,3 ]
机构：
[1] Univ Jaume I Castellon, Sch Hlth Sci Med, Clin & Expt Neurosci NiCE, Castellon De La Plana, Spain
[2] Univ Jaume I Castellon, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Sch Hlth Sci Med, Castellon De La Plana, Spain
[3] Univ Murcia, Sch Med, Murcia, Spain
[4] Inst Rech Servier, Croissy Sur Seine, France
[5] Museum Natl Hist Nat, CNRS, UMR, Brunoy, France
[6] Univ Lille North France, Fac Med, Dept Med Pharmacol, Lille, France
[7] GlaxoSmithKline, R&D China UK Grp, Stevenage, Herts, England
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2013年 / 19卷 / 09期
关键词：
Alzheimer disease; Amyloid beta-protein; Memory; Mild Cognitive Impairment; Octodon degus; AMYLOID-BETA-PEPTIDE; DUAL-PHASING RODENT; SLEEP-DEPRIVATION; A-BETA; OBJECT RECOGNITION; PREFRONTAL CORTEX; SEXUAL-BEHAVIOR; TRANSGENIC MICE; ANIMAL-MODELS; MOUSE MODEL;
D O I：
10.1111/cns.12125
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Octodon degus (O.degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O.degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with aging. Octodon degus spontaneously develops -amyloid deposits analogous to those observed in some cases of Alzheimer's disease (AD). Moreover, these deposits are thought to be the key feature for AD diagnosis, and one of the suggested causes of cell loss and cognitive deficit. This review aims to bring together information to support O.degus as a valuable model for the study of AD.
引用
收藏
页码：643 / 648
页数：6
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