Advances in Rheumatoid Arthritis Animal Models

被引：22
|
作者：
Moudgil, Kamal D. [1 ]
Kim, Peter [2 ]
Brahn, Ernest [2 ]
机构：
[1] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA
[2] UCLA Sch Med, Div Rheumatol, Los Angeles, CA 90095 USA
来源：
CURRENT RHEUMATOLOGY REPORTS | 2011年 / 13卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Rheumatoid arthritis (RA); Animal models; Collagen-induced arthritis (CIA); Adjuvant arthritis (AA); Glucose-6-phosphate isomerase (GPI); Proteoglycan-induced arthritis (PGIA); Cytokines; Interleukin; Tumor necrosis factor-alpha (TNF-alpha); Interferon-gamma (IFN-gamma); CD4+CD25+regulatory T cells (Treg); Dendritic cells (DC); Inflammation; Receptor activator of nuclear factor-kappa B ligand (RANKL); Osteoprotegerin (OPG); Chemokines; Developmental endothelial locus-1 (Del-1); Anticyclic citrullinated peptide (aCCP) antibody; alpha 7-nicotinic acetylcholine receptors (alpha 7nAChRs); Sphingosine-1-phosphate (S1P); Spleen tyrosine kinase (Syk); Janus kinase (JAK)-Interleukin-1 receptor antagonist (IL-1Ra); COLLAGEN-INDUCED ARTHRITIS; REGULATORY T-CELLS; ADJUVANT-INDUCED ARTHRITIS; JOINT INFLAMMATION; BONE EROSION; DESTRUCTION; SUPPRESSION; INHIBITION; CYTOKINE; SUSCEPTIBILITY;
D O I：
10.1007/s11926-011-0200-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Experimental models of rheumatoid arthritis have contributed immensely to our understanding of the pathogenesis as well as the treatment of this debilitating autoimmune disease. Significant progress has been made in the past few years in defining the role of newer cytokines and regulatory T cells, of inflammation-mediated bone and cartilage damage, and of the cholinergic anti-inflammatory pathway in modulating the disease process in arthritis. Furthermore, new therapeutic targets, including specific tyrosine kinases and proteasome subunits, have been explored. These advances offer renewed optimism for continued improvements in the management of rheumatoid arthritis.
引用
收藏
页码：456 / 463
页数：8
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