Therapeutic potential of RAS prenylation pharmacological inhibitors in the treatment of breast cancer, recent progress, and prospective

被引：4

作者：

Soleimani, Atena ^{[1
,2
]}

Amirinejad, Mostafa ^{[3
,4
]}

Rahsepar, Sara ^{[3
]}

Vazirian, Fatemeh ^{[3
]}

Bahrami, Afsane ^{[5
]}

Ferns, Gordon A. ^{[6
]}

Khazaei, Majid ^{[7
,8
]}

Avan, Amir ^{[8
,9
]}

Hassanian, Seyed Mahdi ^{[1
,8
]}

机构：

[1] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Pharm, Student Res Comm, Mashhad, Iran

[5] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[6] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England

[7] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Iran

[8] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[9] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 05期

关键词：

breast cancer (BC); farnesyltransferase inhibitors (FTI); geranylgeranyl transferase (GGTase) inhibitors; RAS prenylation; FARNESYL TRANSFERASE INHIBITOR; PHASE-II TRIAL; FARNESYLTRANSFERASE INHIBITOR; DOXORUBICIN-CYCLOPHOSPHAMIDE; GERANYLGERANYLTRANSFERASE-I; PROTEIN TRANSFERASE; CELL-PROLIFERATION; R115777; TIPIFARNIB; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY;

D O I：

10.1002/jcb.27992

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer is one of the most prevalent malignancies among women around the world. RAS proteins require posttranslational modifications, including protein prenylation for proper membrane localization and signaling. Regulation of RAS signaling via specific and novel pharmacological inhibitors is a potentially novel therapeutic approach in breast cancer therapy. This review summarizes the recent knowledge about the clinical value of RAS prenylation pharmacological inhibitors in breast cancer treatment.

引用

页码：6860 / 6867

页数：8

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