Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

被引：18
|
作者：
Ouattara, Mahama [1 ]
Wein, Sharon [2 ]
Denoyelle, Severine [1 ]
Ortial, Stephanie [1 ]
Durand, Thierry [1 ]
Escale, Roger [1 ]
Vial, Henri [2 ]
Vo-Hoang, Yen [1 ]
机构：
[1] Univ Montpellier 2, Univ Montpellier 1, CNRS, UMR 5247,Inst Biomol Max Mousseron, F-34093 Montpellier, France
[2] Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期
关键词：
C-Alkylamidine; Design of prodrug; Specific O-substitutions; Alkylamidoxime; Clearance of parasitemia; Oral antimalarial agent; PHOSPHOLIPID-METABOLISM; SALTS; PRODRUGS; PENTAMIDINE; ANTAGONISTS; REDUCTION; MOLECULES; AMIDINES;
D O I：
10.1016/j.bmcl.2008.12.058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Within the frame of the design of prodrug candidates to deliver a C-alkylamidine antimalarial agent, we showed that specific O-substitutions were needed on the alkylamidoxime structure. Among the newly synthesized molecules, bis-oxadiazolone and bis-O-methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：624 / 626
页数：3
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