Multiscale agent-based cancer modeling

被引：99

作者：

Zhang, Le ^{[1
]}

Wang, Zhihui ^{[1
]}

Sagotsky, Jonathan A. ^{[1
]}

Deisboeck, Thomas S. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Complex Biosyst Modeling Lab, Harvard MIT HST Athinoula A Martinos Ctr Biomed I, Charlestown, MA 02129 USA

来源：

JOURNAL OF MATHEMATICAL BIOLOGY | 2009年 / 58卷 / 4-5期

关键词：

Computational systems biology; Agent-based modeling; Tumor simulation; EPIDERMAL-GROWTH-FACTOR; CYLINDRICAL SKIN-STRUCTURE; BRAIN-TUMORS; MULTICELLULAR PATTERNS; MATHEMATICAL-MODEL; NUMERICAL-METHOD; CLINICAL-TRIALS; TIME-SERIES; INVASION; GLIOBLASTOMA;

D O I：

10.1007/s00285-008-0211-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Agent-based modeling (ABM) is an in silico technique that is being used in a variety of research areas such as in social sciences, economics and increasingly in biomedicine as an interdisciplinary tool to study the dynamics of complex systems. Here, we describe its applicability to integrative tumor biology research by introducing a multi-scale tumor modeling platform that understands brain cancer as a complex dynamic biosystem. We summarize significant findings of this work, and discuss both challenges and future directions for ABM in the field of cancer research.

引用

页码：545 / 559

页数：15

共 50 条

[1] Multiscale agent-based cancer modeling
Le Zhang
Zhihui Wang
Jonathan A. Sagotsky
Thomas S. Deisboeck
[J]. Journal of Mathematical Biology, 2009, 58 : 545 - 559
[2] Simulating cancer growth with multiscale agent-based modeling
Wang, Zhihui
Butner, Joseph D.
Kerketta, Romica
Cristini, Vittorio
Deisboeck, Thomas S.
[J]. SEMINARS IN CANCER BIOLOGY, 2015, 30 : 70 - 78
[3] Multiscale Agent-Based Consumer Market Modeling
North, Michael J.
Macal, Charles M.
St Aubin, James
Thimmapuram, Prakash
Bragen, Mark
Hahn, June
Karr, James
Brigham, Nancy
Lacy, Mark E.
Hampton, Delaine
[J]. COMPLEXITY, 2010, 15 (05) : 37 - 47
[4] Modeling dynamic multiscale social processes in agent-based models
Ozik, Jonathan
Sallach, David L.
Macal, Charles M.
[J]. IEEE INTELLIGENT SYSTEMS, 2008, 23 (04) : 36 - 42
[5] Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment
Norton, Kerri-Ann
Gong, Chang
Jamalian, Samira
Popel, Aleksander S.
[J]. PROCESSES, 2019, 7 (01)
[6] The Epitheliome Project: Multiscale agent-based modeling of epithelial cells
Smallwood, Rod
Holcombe, Mike
[J]. 2006 3RD IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: MACRO TO NANO, VOLS 1-3, 2006, : 816 - +
[7] Multiscale Pedestrian Modeling with CA and Agent-Based Approaches: Ubiquity or Consistency?
Crociani, Luca
Lammel, Gregor
Vizzari, Giuseppe
[J]. CELLULAR AUTOMATA, ACRI 2016, 2016, 9863 : 415 - 423
[8] Agent-Based Modeling
Khazaii, Javad
[J]. ASHRAE JOURNAL, 2016, 58 (02) : 62 - 64
[9] Agent-based complex system modeling for cancer research
Tsuji, Shingo
Aburatani, Hiroyuki
[J]. CANCER SCIENCE, 2018, 109 : 1045 - 1045
[10] Putting the agent in agent-based modeling
Wellman, Michael P.
[J]. AUTONOMOUS AGENTS AND MULTI-AGENT SYSTEMS, 2016, 30 (06) : 1175 - 1189

← 1 2 3 4 5 →