δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF

被引：10
|
作者：
He, Yongfeng [1 ,2 ]
Kim, Hangun [3 ,4 ]
Ryu, Taeyong [1 ,2 ]
Kang, Youra [5 ]
Kim, Jeong-Ae [5 ]
Kim, Bo-Hyun [6 ]
Lee, Jae-Hyuk [7 ]
Kang, Keonwook [8 ]
Lu, Qun [9 ]
Kim, Kwonseop [1 ,2 ,7 ]
机构：
[1] Chonnam Natl Univ, Coll Pharm, Kwangju, South Korea
[2] Chonnam Natl Univ, Res Inst Drug Dev, Kwangju, South Korea
[3] Sunchon Natl Univ, Coll Pharm, Sunchon, South Korea
[4] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon, South Korea
[5] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea
[6] Chonnam Natl Univ, Sch Biol Sci & Technol, Kwangju, South Korea
[7] Chonnam Natl Univ Hosp, Kwangju, South Korea
[8] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[9] E Carolina Univ, Dept Anat & Cell Biol, Body Sch Med, Greenville, SC USA
来源：
FEBS LETTERS | 2013年 / 587卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
delta-Catenin/NPRAP; Angiogenesis; beta-Catenin; HIF-1; alpha; VEGF; ENDOTHELIAL GROWTH-FACTOR; BETA-CATENIN; E-CADHERIN; LUNG-CANCER; EXPRESSION; PROGRESSION; MECHANISMS; PROTEIN; KAISO;
D O I：
10.1016/j.febslet.2012.11.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study revealed that CWR22Rv-1 cells overexpressing delta-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, delta-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) expression. Furthermore, delta-catenin overexpression was found to enhance nuclear distribution of both beta-catenin and HIF-1 alpha in hypoxic condition, which is diminished by knockdown of delta-catenin. Our current study adds novel evidence regarding contribution of delta-catenin to the progression of prostate cancer. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：193 / 199
页数：7
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