Viral respiratory tract infections and asthma in early life: cause and effect?

被引：0
|
作者：
Mackenzie, K. J. [1 ]
Anderton, S. M. [1 ,2 ,3 ]
Schwarze, J. [1 ,4 ]
机构：
[1] Univ Edinburgh, MRC Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Univ Edinburgh, Ctr Multiple Sclerosis Res, Edinburgh EH16 4TJ, Midlothian, Scotland
[3] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh EH16 4TJ, Midlothian, Scotland
[4] Univ Edinburgh, Edinburgh EH16 4TJ, Midlothian, Scotland
来源：
CLINICAL AND EXPERIMENTAL ALLERGY | 2014年 / 44卷 / 01期
基金：
英国医学研究理事会;
关键词：
INNATE LYMPHOID-CELLS; SYNCYTIAL VIRUS-INFECTION; THYMIC STROMAL LYMPHOPOIETIN; ALLERGIC AIRWAY INFLAMMATION; LUNG DENDRITIC CELLS; EPITHELIAL-CELLS; EOSINOPHILIC INFLAMMATION; RSV BRONCHIOLITIS; PERSISTENT ACTIVATION; RHINOVIRUS ILLNESSES;
D O I：
10.1111/cea.12139
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Interactions between viral respiratory tract infections in infancy and childhood, and asthma development and exacerbation, are complex and intriguing. This review aims to unravel some of these complexities. Does severe respiratory viral infection early in life predispose to later asthma development, or is it indicative of a predisposition to allergic respiratory disease? How could variables such as age and severity of viral infection affect the interaction between respiratory viral infections and asthma? How could respiratory viral infection drive allergic sensitization? Here, we review the evidence surrounding these questions, and discuss current and future research and therapeutic approaches targeting the interplay between viral respiratory tract infection and asthma.
引用
收藏
页码：9 / 19
页数：11
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