Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains

被引：22
|
作者：
Kodama, C
Matsui, H
机构：
[1] Kitasato Univ, Kitasato Inst Life Sci,Grad Sci Infect Control Sc, Dept Infect Control & Immunol, Immunol Lab,Minato Ku, Tokyo 1088641, Japan
[2] Kitasato Inst, Ctr Basic Res, Minato Ku, Tokyo 1088642, Japan
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 04期
关键词：
D O I：
10.1128/IAI.72.4.2449-2451.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.
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页码：2449 / 2451
页数：3
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