The Epstein-Barr virus: a group 1 carcinogen?

被引：25
|
作者：
Niedobitek, G [1 ]
机构：
[1] Univ Erlangen Nurnberg, Inst Pathol, D-91054 Erlangen, Germany
来源：
VIRCHOWS ARCHIV | 1999年 / 435卷 / 02期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Epstein-Barr virus; latent membrane protein 1; post-transplant lymphoproliferative disorder Hodgkin's disease; T-cell lymphoma; nasopharyngeal carcinoma;
D O I：
10.1007/s004280050402
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The Epstein-Barr virus (EBV) is a human herpes virus with the ability to transform B-lymphocytes in vitro. EBV has been linked to the pathogenesis of a variety of human tumours, including Burkitt's lymphoma, immunosuppression-related lymphomas, Hodgkin's disease, nasal angiocentric T/NK-cell lymphoma and nasopharyngeal carcinoma. Based on the association of the virus with these tumours, EBV has been classified as a group 1 carcinogen by the WHO International Agency for Research on Cancer. In this article, the evidence suggesting that EBV is carcinogenic to humans is briefly reviewed.
引用
收藏
页码：79 / 86
页数：8
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