Mechanisms of Drug-induced Liver Injury

被引：222

作者：

Yuan, Liyun ^{[1
]}

Kaplowitz, Neil ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Med, USC Res Ctr Liver Dis, Los Angeles, CA 90033 USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 04期

关键词：

Idiosyncratic drug-induced liver injury; Cell death; Reactive metabolites; Oxidative stress; Stress signaling; Mitochondria; Adaptive immunity; HLA associations; MITOCHONDRIAL DYSFUNCTION; POSITIONAL ISOMER; ORAL MEDICATIONS; CELL-DEATH; ACETAMINOPHEN; NECROSIS; PROTEIN; 3'-HYDROXYACETANILIDE; INHIBITION; APOPTOSIS;

D O I：

10.1016/j.cld.2013.07.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Drug-induced liver injury (DILI) represents a broad spectrum of liver manifestations. However, the most common manifestation is hepatocyte death following drug intake. DILI can be predictable and dose dependent with a notable example of acetaminophen toxicity. Idiosyncratic DILI occurs in an unpredictable fashion at low frequencies, implying that environmental and genetic factors alter the susceptibility of individuals to the insult (drugs).

引用

页码：507 / +

页数：13

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