SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease

被引：87

作者：

Wang, Pengfei ^{[1
]}

Liu, Lihong ^{[1
]}

Nair, Manoj S. ^{[1
]}

Yin, Michael T. ^{[2
]}

Luo, Yang ^{[1
]}

Wang, Qian ^{[3
]}

Yuan, Ting ^{[1
]}

Mori, Kanako ^{[1
]}

Solis, Axel Guzman ^{[1
]}

Yamashita, Masahiro ^{[1
]}

Garg, Ankur ^{[4
]}

Purpura, Lawrence J. ^{[2
]}

Laracy, Justin C. ^{[2
]}

Yu, Jian ^{[1
]}

Joshua-Tor, Leemor ^{[4
]}

Sodroski, Joseph ^{[3
]}

Huang, Yaoxing ^{[1
]}

Ho, David D. ^{[1
]}

机构：

[1] Columbia Univ, Vagelos Coll Phys & Surg, Aaron Diamond AIDS Res Ctr, 701 W 168th St, New York, NY 10032 USA

[2] Columbia Univ, Vagelos Coll Phys & Surg, Dept Internal Med, Div Infect Dis, New York, NY USA

[3] Harvard Med Sch, Dept Microbiol, Dana Farber Canc Inst, Dept Canc Immunol & Virol, Boston, MA 02115 USA

[4] Cold Spring Harbor Lab, WM Keck Struct Biol Lab, POB 100, Cold Spring Harbor, NY 11724 USA

来源：

EMERGING MICROBES & INFECTIONS | 2020年 / 9卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; antibody; neutralization; severe; non-severe;

D O I：

10.1080/22221751.2020.1823890

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by similar to 5-fold and similar to 7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

引用

页码：2091 / 2093

页数：3

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