Between a rock and a hard place?

被引：151

作者：

Whitty, A ^{[1
]}

Kumaravel, G ^{[1
]}

机构：

[1] Biogen Idec Inc, Drug Discovery Dept, Cambridge, MA 02142 USA

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 03期

关键词：

D O I：

10.1038/nchembio0306-112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain. © 2006 Nature Publishing Group.

引用

页码：112 / 118

页数：7

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