External Validation of TNM-C Score in Three Community Hospital Cohorts for Clear Cell Renal Cell Carcinoma

被引：0

作者：

Nakayama, Takayuki ^{[1
,2
]}

Saito, Kazutaka ^{[1
]}

Ishioka, Junichiro ^{[1
,2
]}

Kawano, Keizo ^{[2
]}

Morimoto, Shinji ^{[2
]}

Matsuoka, Yoh ^{[1
,3
]}

Okuno, Tetsuo ^{[3
]}

Moriyama, Shingo ^{[4
]}

Takeshita, Hideki ^{[1
,4
]}

Noro, Akira ^{[4
]}

Fujii, Yasuhisa ^{[1
]}

Kihara, Kazunori ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Urol, Grad Sch, Tokyo 1138519, Japan

[2] Tsuchiura Kyodo Gen Hosp, Dept Urol, Tsuchiura, Ibaraki, Japan

[3] Toride Kyodo Gen Hosp, Dept Urol, Toride, Japan

[4] Saitama Red Cross Hosp, Dept Urol, Saitama, Japan

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 02期

关键词：

Renal cell carcinoma; prognosis; C-reactive protein; TNM classification; nephrectomy; RADICAL NEPHRECTOMY; SURVIVAL; CANCER; IMPACT; STAGE; MODEL; CRP;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess the general applicability of TNM-C scoring, which consists of TNM classification and preoperative C-reactive protein concentration, the predictive ability of the TNM-C score was externally validated for patients with clear cell renal cell carcinoma (ccRCC) at three community hospitals. Patients and Methods: Seven hundred patients underwent radical or partial nephrectomy after being diagnosed with RCC: Out of the 700 patients, 518 with clear cell carcinoma served as the current study cohort. The predictive ability of the TMN-C score for cancer-specific survival (CSS) was estimated using Harrell's concordance index (c-index). Results: The c-index of the TNM-C score was 0.85 in the entire data set. CSS rates were clearly stratified according to the scoring model (p<0.001). Conclusion: Since TNM-C score alone (without pathological details) has a high predictive ability for the prognosis of ccRCC patients, it is generally applicable for use in community hospitals.

引用

页码：921 / 926

页数：6

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