A p-value for testing the equivalence of the variances of a bivariate normal distribution

被引:0
|
作者
Mathew, Thomas [1 ]
Paul, Gitanjali [1 ,2 ]
机构
[1] Univ Maryland, Dept Math & Stat, Baltimore, MD 21250 USA
[2] GlaxoSmithKline Inc, King Of Prussia, PA 19406 USA
关键词
bioequivalence; crossover design; incomplete beta; Wishart distribution;
D O I
10.1016/j.jspi.2008.02.005
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
A p-value is developed for testing the equivalence of the variances of a bivariate normal distribution. The unknown correlation coefficient is a nuisance parameter in the problem. If the correlation is known, the proposed p-value provides an exact test. For large samples, the p-value can be computed by replacing the unknown correlation by the sample correlation, and the resulting test is quite satisfactory. For small samples, it is proposed to compute the p-value by replacing the unknown correlation by a scalar multiple of the sample correlation. However, a single scalar is not satisfactory, and it is proposed to use different scalars depending on the magnitude of the sample correlation coefficient. In order to implement this approach, tables are obtained providing sub-intervals for the sample correlation coefficient, and the scalars to be used if the sample correlation coefficient belongs to a particular sub-interval. Once such tables are available, the proposed p-value is quite easy to compute since it has an explicit analytic expression. Numerical results on the type I error probability and power are reported on the performance of such a test, and the proposed p-value test is also compared to another test based on a rejection region. The results are illustrated with two examples: an example dealing with the comparability of two measuring devices, and an example dealing with the assessment of bioequivalence. (C) 2008 Elsevier B.V. All rights reserved.
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页码:3982 / 3992
页数:11
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