Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release

被引：25
|
作者：
Cheng, Cheng
Wei, Hua
Zhang, Xian-Zheng [1 ]
Cheng, Si-Xue
Zhuo, Ren-Xi
机构：
[1] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2009年 / 88A卷 / 03期
基金：
中国国家自然科学基金;
关键词：
biotin-P(NIPAAm-co-HMAAm)-b-PMMA; thermoresponsive micelle; CEIA-CL; controlled release; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DELIVERY; POLY(N-ISOPROPYLACRYLAMIDE); NANOPARTICLES; DESIGN;
D O I：
10.1002/jbm.a.31770
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Thermosensitive and biotinylated biotin-poly (N-isopropylacrylamide-co-N-hydroxymethylacrylamide)block-poly(methyl methacrylate) (biotin-P(NIPAAm-co-HMAAm)-b-PMMA) block copolymers were designed and synthesized. The conjugation of biotin molecule with the copolymer as well as the capability of easily functionalizing with ligands for pretargeting approach of the biotinylated Multifunctional drug carrier was confirmed by a novel method called capillary electrophoresis immunoassay (CEIA) based on enhanced chemiluminescence (CL) detection. The biotin-P(NIPAAm-co-HMAAm)-b-PMMA copolymer was capable of self-assembling into nanometer-sized micelle. The anticancer drug methotrexate (MTX), used as a model drug, was loaded in the self-assembled micelles and the thermo-triggered release behavior of MTX was investigated. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 814-822, 2009
引用
收藏
页码：814 / 822
页数：9
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