Transition-Metal-Free Synthesis of Ynones via Decarboxylative Alkynylation of α-Keto Acids under Mild Conditions

被引：29

作者：

Wang, Peng-Fei ^{[1
,2
]}

Feng, Yi-Si ^{[1
,2
,3
]}

Cheng, Zhi-Fei ^{[1
,2
]}

Wu, Qiu-Min ^{[1
,2
]}

Wang, Guang-Yu ^{[1
,2
]}

Liu, Liang-Liang ^{[1
,2
]}

Dai, Jian-Jun

Xu, Jun

Xu, Hua-Jian ^{[3
]}

机构：

[1] Hefei Univ Technol, Sch Chem & Chem Engn, Hefei 230009, Peoples R China

[2] Hefei Univ Technol, Sch Med Engn, Hefei 230009, Peoples R China

[3] Anhui Key Lab Controllable Chem React & Mat Chem, Hefei 230009, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 18期

基金：

中国国家自然科学基金;

关键词：

ALIPHATIC CARBOXYLIC-ACIDS; CROSS-COUPLING REACTION; ARYL HALIDES; POTASSIUM POLYFLUOROBENZOATES; AROMATIC CARBOXYLATES; PYRIMIDINE SYNTHESIS; TERMINAL ALKYNES; BIARYL SYNTHESIS; SALTS; ACTIVATION;

D O I：

10.1021/acs.joc.5b01387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of alpha-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical process is proposed in the reaction.

引用

页码：9314 / 9320

页数：7

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