Atherosclerosis and the lectin-like OXidized low-density lipoprotein scavenger receptor

被引：66
|
作者：
Vohra, RS
Murphy, JE
Walker, JH
Ponnambalam, S
Homer-Vanniasinkam, S
机构：
[1] Gen Infirm, Leeds Vasc Inst, Leeds LS1 3EX, W Yorkshire, England
[2] Univ Leeds, Fac Biol Sci, Endothelial Cell Biol Unit, Leeds LS2 9JT, W Yorkshire, England
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2006年 / 16卷 / 02期
基金：
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1016/j.tcm.2005.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.
引用
收藏
页码：60 / 64
页数：5
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