Scale-up of Human Mesenchymal Stem Cells on Microcarriers in Suspension in a Single-use Bioreactor

被引：0
|
作者：
Kehoe, Daniel [1 ]
Schnitzler, Aletta [2 ]
Simler, Janice [1 ]
DiLeo, Anthony [3 ]
Ball, Andrew [4 ]
机构：
[1] EMD Millipore, Proc Solut, Billerica, MA USA
[2] EMD Millipore, Pharmaceut Chem Solut, Billerica, MA USA
[3] EMD Millipore, Corp Technol Off, Billerica, MA USA
[4] EMD Millipore, Syst Pharmacol, Billerica, MA USA
来源：
BIOPHARM INTERNATIONAL | 2012年 / 25卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Clinical demand for mesenchymal stem cells (MSCs) drives the need for development of robust large-scale production. This study demonstrates the utility of a 3-L single-use bioreactor and collagen-coated microcarriers for the expansion of human bone marrow derived MSCs. This proof of principle study is a demonstration of the potential for large-scale stem-cell scale-up using stirred bioreactors.
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页码：28 / +
页数：9
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