Immunological recovery after 3 years' antiretroviral therapy in HIV-1-infected children

被引：19
|
作者：
Resino, S [1 ]
Sanchez-Ramón, S [1 ]
Bellón, JM [1 ]
Correa, R [1 ]
Abad, ML [1 ]
Muñoz-Fernández, MA [1 ]
机构：
[1] Gen Univ Hosp Gregorio Maranon, Dept Immunol, Madrid, Spain
来源：
AIDS | 2002年 / 16卷 / 03期
关键词：
D O I：
10.1097/00002030-200202150-00022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To characterize the immune reconstitution in vertically HIV-1-infected category C3 children after 3 years' antiretroviral therapy (ART), 22 children were studied longitudinally. Children who achieved high CD4 T cell counts and T cell receptor rearrangement excision circles and low viral loads after ART showed values of naive T cells very close to age-matched long-term asymptomatic children or healthy controls. Our data indicate that in C3 children who respond to ART, the immune system may recover fully in quantitative and functional terms.
引用
收藏
页码：483 / 486
页数：4
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