Separation of steroid isomers by ion mobility mass spectrometry

被引：72

作者：

Ahonen, Linda ^{[1
]}

Fasciotti, Maira ^{[2
,3
]}

af Gennas, Gustav Boije ^{[1
]}

Kotiaho, Tapio ^{[1
,4
]}

Daroda, Romeu J. ^{[3
]}

Eberlin, Marcos ^{[2
]}

Kostiainen, Risto ^{[1
]}

机构：

[1] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem, FI-00014 Helsinki, Finland

[2] Univ Estadual Campinas, ThoMSon Mass Spectrometry Lab, Inst Chem, UNICAMP, BR-13083970 Campinas, SP, Brazil

[3] INMETRO, Natl Inst Metrol Qual & Technol, Div Chem, BR-25250020 Duque De Caixas, RJ, Brazil

[4] Univ Helsinki, Dept Chem, Analyt Chem Lab, SF-00100 Helsinki, Finland

来源：

JOURNAL OF CHROMATOGRAPHY A | 2013年 / 1310卷

基金：

芬兰科学院;

关键词：

Ion mobility mass spectrometry; Steroids; Steroid isomers; Derivatization; Collision cross section; ANABOLIC-ANDROGENIC STEROIDS; CHROMATOGRAPHY/MASS SPECTROMETRY; HUMAN BRAIN; HUMAN SERUM; NEUROSTEROIDS; TESTOSTERONE; GAS; METABOLITES; IONIZATION; ESTROGEN;

D O I：

10.1016/j.chroma.2013.08.056

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ion mobility mass spectrometry performed in a compact traveling wave cell (TWIM-MS) is shown to provide a reliable, fast and repeatable method to separate derivatized steroid isomers. Three steroid isomer pairs were analyzed in their native form and as their p-toluenesulfonyl isocyanate derivatives. The native steroids were separated from each other, but no separation could be attained for the isomers. The derivatized steroid isomers were, however, properly separated by TWIM-MS with peak-to-peak resolutions close to or as high as baseline resolution (Rp-p = 0.77-1.08). (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：133 / 137

页数：5

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