The multidimensional nature of metabolic syndrome in schizophrenia: lessons from studies of one-carbon metabolism and DNA methylation

被引：0
|
作者：
Misiak, Blazej [1 ]
Frydecka, Dorota [1 ]
Piotrowski, Patryk [1 ]
Kiejna, Andrzej [1 ]
机构：
[1] Wroclaw Med Univ, Dept Psychiat, PL-51367 Wroclaw, Poland
来源：
EPIGENOMICS | 2013年 / 5卷 / 03期
关键词：
DNA methylation; epigenetics; metabolic syndrome; one-carbon metabolism; schizophrenia; CORONARY-ARTERY-DISEASE; DRUG-NAIVE PATIENTS; INDUCED WEIGHT-GAIN; VISCERAL FAT DISTRIBUTION; S-ADENOSYL METHIONINE; MB-COMT PROMOTER; RISK-FACTORS; METHYLENETETRAHYDROFOLATE REDUCTASE; EPIGENETIC REGULATION; HOMOCYSTEINE LEVELS;
D O I：
10.2217/EPI.13.22
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Large data sets indicate that the prevalence of metabolic syndrome (MetS) is significantly higher in patients with schizophrenia in comparison with the general population. Given that interactions between genes and the environment may underlie the etiology of MetS in subjects with schizophrenia, it is feasible that epigenetic phenomena can serve as the etiological consensus between genetic and environmental factors. However, there is still a striking scarcity of studies aimed at investigating the role of aberrant DNA methylation in the development of MetS in this group of patients. This article provides an update on the epigenetics of schizophrenia and reviews studies on the role of one-carbon metabolism and aberrant DNA methylation in the development of MetS.
引用
收藏
页码：317 / 329
页数：13
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