Targeted Therapy: A New Approach for the Treatment of Locally Advanced Oropharyngeal Cancer

被引：0
|
作者：
Velsher, L. Z. [1 ,2 ]
Kosmynin, A. A. [1 ]
Byakhov, M. Yu [1 ,2 ]
Duditskaya, T. K. [1 ,2 ]
Reshetov, D. N. [1 ,2 ]
机构：
[1] Moscow State Med & Dent Univ, Moscow, Russia
[2] Canc Ctr JSC RZD, Moscow, Russia
来源：
ACTA NATURAE | 2012年 / 4卷 / 01期
关键词：
oropharyngeal cancers; targeted therapy; quality of life; gefitinib; SQUAMOUS-CELL CARCINOMA; NECK-CANCER; LUNG-CANCER; HEAD; GEFITINIB; MUTATIONS; CHEMOTHERAPY; CETUXIMAB;
D O I：
10.32607/20758251-2012-4-1-82-85
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Presented herein is a clinical study comprising 48 patients (42 men and 6 women) of working age (40-70 years), all of whom are suffering from locally advanced oropharyngeal cancer. A modern approach is applied to treat these patients, i.e., neoadjuvant targeted therapy, taking into account the biological profile of the tumor. The use of gefitinib causes an antitumor effect in 90.5% of cases as opposed to 56.5% when no drug is applied.
引用
收藏
页码：82 / 85
页数：4
相关论文
共 50 条
  • [1] LOCALLY ADVANCED OROPHARYNGEAL CANCER IN THE ELDERLY - TREATMENT COMPLIANCE AND OUTCOME
    Geropantas, K.
    Loo, S.
    Martin, C.
    Roques, T.
    [J]. RADIOTHERAPY AND ONCOLOGY, 2011, 98 : S23 - S23
  • [2] Targeted therapy for locally advanced and/or metastatic bladder cancer
    Wallerand, H.
    Robert, G.
    Bernhard, J. -C.
    Ravaud, A.
    Ferriere, J. -M.
    [J]. PROGRES EN UROLOGIE, 2008, 18 (07): : 407 - 417
  • [3] Targeted Therapy for Early and Locally Advanced Breast Cancer
    Untch, Michael
    [J]. BREAST CARE, 2010, 5 (03) : 144 - 152
  • [4] Vandetanib: A novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer
    Ton, GiangThy N.
    Banaszynski, Megan E.
    Kolesar, Jill M.
    [J]. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2013, 70 (10) : 849 - 855
  • [5] Concurrent chemoradiation for locally advanced oropharyngeal cancer
    Nguyen, Nam P.
    Vos, Paul
    Smith, Herbert J.
    Nguyen, Phuc D.
    Alfieri, Alan
    Karlsson, Ulf
    Dutta, Suresh
    Lemanski, Claire
    Nguyen, Ly M.
    Sallah, Sabah
    [J]. AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2007, 28 (01) : 3 - 8
  • [6] Surgical Options for Locally Advanced Oropharyngeal Cancer
    Hannan A. Qureshi
    Marianne Abouyared
    Brittany Barber
    Jeffrey J. Houlton
    [J]. Current Treatment Options in Oncology, 2019, 20
  • [7] Surgical Options for Locally Advanced Oropharyngeal Cancer
    Qureshi, Hannan A.
    Abouyared, Marianne
    Barber, Brittany
    Houlton, Jeffrey J.
    [J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2019, 20 (05)
  • [8] Locally advanced oropharyngeal cancer: a dynamic nomogram
    De Felice, F.
    Humbert-Vidan, L.
    Lei, M.
    King, A.
    Urbano, T. Guerrero
    [J]. RADIOTHERAPY AND ONCOLOGY, 2021, 161 : S804 - S805
  • [9] Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review
    Chitsike, Lennox
    Duerksen-Hughes, Penelope J.
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [10] Accelerated split-course chemoradicitherapy in the treatment of locally advanced oropharyngeal cancer
    Vinogradov, V.
    Vasillevskaya, I.
    Ladanova, T.
    Girshovitch, A.
    [J]. RADIOTHERAPY AND ONCOLOGY, 2007, 82 : S46 - S46
12345