Safety and Immunogenicity of a Meningococcal (Groups A, C, Y, W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Children Aged 2 to 10 Years in Chile

被引：5
|
作者：
Lagos, Rosanna [1 ]
Papa, Thomas [2 ]
Munoz, Alma
Ryall, Robert [2 ]
Pina, Miriam [2 ]
Bassily, Ehab [2 ]
机构：
[1] Hosp Ninos Roberto Rio, Ctr Vacunas Desarrollo Chile, Santiago, Chile
[2] Sanofi Pasteur Inc, Swiftwater, PA USA
来源：
HUMAN VACCINES | 2005年 / 1卷 / 06期
关键词：
meningococcal disease; vaccine; immunogenicity; children; conjugate vaccine;
D O I：
10.4161/hv.1.6.2301
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Immune responses to meningococcal conjugate (Menactra (TM); MCV-4) and plain polysaccharide (Menomune (R)-A/C/Y/W-135; PSV-4) vaccines against serogroups A, C, Y, and W-135 were assessed in 220 of 1037 Chilean children aged 2 to 10 years participating in a comparative safety trial. Both vaccines were generally well tolerated. Geometric mean serum bactericidal antibody (SBA) titers 28 days postvaccination were comparable in both groups for all four serogroups. Seroconversion was evident in > 97% of MCV-4 and > 90% of PSV-4 vaccinees who tested seronegative at baseline. Menactra (TM) safely induced broad and robust immune responses against serogroups A, C, Y and W-135 in this population.
引用
收藏
页码：228 / 231
页数：4
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