Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats

被引:93
|
作者
Cho, S
Joh, TH
Baik, HW
Dibinis, C
Volpe, BT
机构
[1] CORNELL UNIV,COLL MED,BURKE MED RES INST,DEPT NEUROL & NEUROSCI,WHITE PLAINS,NY 10605
[2] CORNELL UNIV,COLL MED,BURKE MED RES INST,MOL BIOL LAB,WHITE PLAINS,NY 10605
关键词
ischemia; hippocampus; melatonin; protection;
D O I
10.1016/S0006-8993(97)00188-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Melatonin administered at the beginning of cerebral reperfusion protected CA1 neurons against 10, 20 and 30 min of transient forebrain ischemia. Intraperitoneal injections of saline or melatonin (10 mg/kg) were given after 0, 2 and 6 h, or 1, 2 and 6 h of cerebral reperfusion, or 30 min prior to ischemia. One week later, quantitative histological analysis demonstrated that CAI neuronal density was significantly increased in the melatonin groups that were treated at 0, 2, 6 h compared to the saline-treated controls. Ischemic protection of CA1 was lost in the animals in which the melatonin treatment was delayed by 1 h, or given 30 min prior to the ischemia.
引用
收藏
页码:335 / 338
页数:4
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